About ens@t-ht

What is ens@t-ht? What is arterial hypertension?

 

Who?

Who is involved? 

Progress

Find out how we are getting on with the project through our regular updates

What is ens@t-ht?

ens@t-ht is an EU-funded Horizon 2020 research and innovation project that will investigate specific types of hypertension and whether it is possible to define specific profiles based on systems biology "-omics" approaches and subsequently use these to define more personalised approaches to disease management

In more detail...

The project will develop and evaluate an omics-based stratified health promotion programme for patients with endocrine forms of hypertension.

We will define specific omics profiles for patients with primary aldosteronism, pheochromocytoma/functional paraganglioma and Cushing’s syndrome by integrating high throughput genetics, genomics and metabolomics data with phenome annotations through bioinformatics modelling.

Established profiles will be validated as stratification biomarkers and applied to the screening of referred hypertensive patients for both stratifying primary forms of hypertension for effective and cost efficient therapy as well as improving identification of endocrine causes for curative treatment and prevention of cardiovascular and metabolic complications.

Omics-based profiling should allow identification of patients with preclinical phenotypes along with those hypertensives that cluster into specific endocrine groups who may benefit from personalized treatment.

The broader context of hypertension

Arterial hypertension affects about 45% of the general population and is responsible for 7.1 million deaths per year worldwide. Although a large therapeutic arsenal exists, blood pressure control is sub-optimal in up to two thirds of patients. Yet, even small increments in blood pressure are associated with increased cardiovascular risk, with 62% of cerebrovascular disease and 49% of ischemic heart disease being attributable to hypertension.

Disease context of ens@t-ht

Detection of secondary forms of hypertension is key to targeted management of the underlying disease and prevention of cardiovascular complications. Endocrine forms of hypertension represent major targets for stratified approaches of health promotion.

They include a group of adrenal disorders resulting in increased production of hormones affecting blood pressure regulation: primary aldosteronism (PA), pheochromocytoma/functional paraganglioma (PPGL) and Cushing’s syndrome (CS). These diseases are associated with increased cardiovascular and metabolic risk and with diminished quality of life.

For ens@t-ht these diseases will form the major targets for our investigation into whether disease profiles can be defined via -omics and bioinformatics approaches and whether more personalised approaches to treatment and disease management are possible.

In short

  • You can find out much more about our project and clinical study on this site. We have included many details on the context of the project and there is much more information to come soon.
  • If you are a patient with hypertension, and specifically the diseases mentioned above, there may be opportunities to get involved in the project. More information will be coming soon on that.
  • Want to know who we are? You can find out more about the consortium here.
  • Latest updates about the project? News and events will cover all of that.
  • Results? When we have them, they will be here.
  • Want to contact us? Go here.
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People

Scientific Coordinator: Dr Maria -Christina Zennaro, Head of INSERM U970 team 14: Genetic mechanisms of aldosterone-related disorders. maria-christina.zennaro@inserm.fr

Project Manager (INSERM-Transfert): Catherine Clusel catherine.clusel@inserm-transfert.fr

Project Manager (INSERM-Transfert): Kristina Fiedler kristina.fiedler@inserm-transfert.fr

More contact details here

Places

Paris Cardiovascular Research Center (PARCC), European Georges Pompidou Hospital, 56 rue Leblanc, 75015 Paris, France

INSERM-Transfert, Paris Biopark, 7 rue Watt, 75013 Paris, France

Funding

This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 633983

Maps

European Georges Pompidou Hospital


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INSERM-Transfert


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